Pauley Perrette
A favorite among fans of NCIS, Pauley Perrette was memorable for playing a quirky forensic examiner by the name of Abby. Fans were confused by her departure because it felt like it came from out of nowhere. On top of that, it meant that she would give up a huge salary. She later took to Twitter to say that she and the rest of the cast had been butting heads when it comes to the creative direction of the show. In her quest to seek fulfillment, she has said that she will likely never come back to the show.
Lecy Goranson
Over the years, Roseanne has seen different kinds of Beckys. However, it is hard to beat the first one, played by none other than Lecy Goranson. The actress abandoned the role of Becky Conner in the fourth season in order to go to Vassar College fulltime. She did not leave for good, however. The actress even came back for the final season! On top of that, she was set to work on the reboot of the show, but the revival was eventually canceled after the original star Roseanne Barr posted racist tweets.